NoDep is a dietary supplement useful in treating mild or moderate depression, exerting a positive effect on mood. NoDep are excellent natural remedies to combat the symptoms of physical and mental fatigue. Based on titrated extracts of Hypericum and Withania, they also contain Magnesium and Vitamin B6. The hypericum (Hypericum perforatum) is a plant of the Hypericaceae family, aka "St. John's Worth", it is traditionally known since ancient times to have an antidepressant and sedative action, which is obtained from the dry extract or from mother tincture. Thanks to the presence of Magnesium and Vitamin B6, which contribute to the reduction of tiredness and fatigue, this line of natural supplements against physical and mental fatigue and mood disorders in general, represents a valid ally as a moderate antidepressant and anxiolytic. Orally, it can be useful to regulate sleep and mood during disorders related to seasonality, age, hormonal changes such as menopause or to particular moments of life.